Topic: Kv1 potassium channels

Autoantibodies against LGI1 cause limbic encephalitis with characteristic focal epileptic seizures and memory disorders. LGI1 is secreted by neurons and consists of two functional domains: a leucine-rich (LRR) and an epitempin (EPTP) region and forms complexes in synapses and axons via the receptors ADAM22/23 with Kv1 potassium channels and structural proteins such as PSD95 and glutamate receptors, whereby LGI1 can exert an influence on synaptic transmission and intrinsic excitability. To understand changes in neuronal function by LGI1 encephalitis, we used patients’ serum IgGs or monoclonal a

The dorsal lateral geniculate nucleus (dLGN) has long been held to act as a basic relay for visual information travelling from the retina to cortical areas, but recent findings suggest a largely underestimated functional plasticity of dLGN neurons. However, the cellular mechanisms supporting this functional plasticity have not been yet explored. In particular, it remains to elucidate whether intrinsic neuronal excitability change upon visual stimuli. We show here that monocular deprivation for 10 days reduces the intrinsic excitability of dorsal LGN relay cells. Furthermore, dLGN neurons exhib