Topic: large-scale electrophysiological recordings

The functional organization of cerebral cortex comprises several motifs, including feedforward, feedback, and horizontal interactions across areas and layers. Modern recording techniques now allow us to record from many neurons across these populations. However, especially as we consider multiple (more than two) populations, new conceptual and statistical frameworks are needed to reveal the population-level nature of these organizational motifs and how they contribute to brain function. Here, we advance the use of the dimensionality reduction approach group factor analysis (GFA), alongside la

Cognitive flexibility is necessary for efficient disengagement from a previous task or reconfiguring and implementing new responses to a novel demand. The orbitofrontal cortex is associated with value encoding and is crucial for flexibility to switch behaviours in front of unexpected outcomes. However, the neuronal mechanisms behind such flexibility to modify the encoded value are unknown. We aim to determine the dynamical mechanisms of orbitofrontal neuronal circuits involved in value-based decisions across different environmental contingencies. For this purpose, we perform large-scale electr