Topic: lateral feedback inhibition

Correlative Hebbian learning rules are broadly supported by experimental evidence, but do not prescribe a mechanism to coordinate plasticity across multiple circuit layers during target-directed learning. Recent experimental and theoretical work suggests that top-down input to the apical dendrites of pyramidal cells may provide a solution to this deep credit assignment problem. Experiments have shown that dendritic-spike-dependent plasticity is promoted by top-down excitatory inputs carrying information about learning targets, and it is suppressed by lateral feedback inhibition. However, exist

Environmental enrichment improves hippocampus-dependent spatial learning and memory. However, how enrichment influences hippocampal network activity remains still largely unclear.Using cFos labeling, we showed that exploration of a novel context leads to increased cFos activity in hippocampal principal neurons in mice housed under both standard and enrichment conditions. Remarkably, the number of cFos-expressing cells was lower in enriched mice. Additionally, we recorded Ca2+ responses in CA1 pyramidal cells (PCs) using miniature microscope in mice performing exploration. We observed lower eve