Topic: lateral mammillary nucleus

Continuous attractor networks are believed to support various cognitive functions, from working memory to spatial representations, yet the neuronal dynamics and circuits supporting these dynamics in vivo remain unclear. One example of such networks is the head-direction (HD) circuit, a crucial signal for navigation. It is represented by HD cells, which each fire for a specific direction of the animal’s head, and is transmitted to the cortex by the anterodorsal nucleus (ADN) of the thalamus where a vast majority of neurons are modulated by HD. ADn HD cells maintain their mutual coordination dur

The head-direction (HD) system is an essential component of the spatial navigation system and is believed to provide key signals during sleep to support memory formation in the downstream parahippocampal regions. The HD signal is processed by a mammillary-thalamic-subicular loop within the Papez circuits. Specifically, the lateral mammillary nucleus (LMN) receives an angular velocity signal from the brainstem and is believed to form an attractor network supporting the generation of the HD signal. By recording from ensembles of LMN neurons in freely moving mice during wakefulness and sleep, we

The Head Direction (HD) system is important for spatial orientation. The Anterior thalamic nucleus (ATN) is one of the critical brain regions for the system. It is composed of two main subdivisions: the anterodorsal nucleus (AD) and anteroventral nucleus (AV). It receives HD inputs originated from the lateral mammillary nucleus (LMN), and it sends HD information to the retrosplenial cortex (RSC) and presubiculum (PrS). However, it has been unclear which thalamic neurons target RSC or PrS. Moreover, the input connectivity from the upstream lateral mammillary nucleus (LMN) is has not been clearl