Topic: lateral OFC

The orbitofrontal cortex (OFC) has long been considered critical for value-based decision making, but its precise role is a point of contention. One hypothesis is that OFC computes subjective value and drives economic choice [1]. A second hypothesis is that OFC represents a cognitive map or state space (i.e., a representation of the different states in a task and the transitions between them) [2]. We trained rats on a novel temporal wagering task with partially hidden states (blocks of trials with low or high rewards). Rats must determine how long to wait for a reward, providing an explicit be

Animals continuously evaluate past and current sensory and contextual information to make appropriate decisions during behaviour. How animals employ specific behavioural strategies while learning a task and how the orbitofrontal cortex (OFC) contributes to such strategy-based learning remains understudied. To investigate this, we trained mice on a tactile reversal learning task and implemented a trial-resolution Bayesian evidence accumulation model to measure the probability of the strategies used. We analysed multiple exploratory strategies across key task-learning phases and subsequently aft