Topic: layer 2/3 pyramidal cells

The concept of homeostasis is a central principle in many biological systems, and aims at maintaining systems in a functional state. In the brain homeostatic synaptic plasticity is a well-known mechanism to maintain neuronal networks in a functional homeostasis. Despite there has been a lot of research and characterization of this form of plasticity in animal models, it remains unknown, whether it is also expressed in the human brain. In this study, we investigated the impact of treatment with antiepileptic drugs on neurotransmission and functional properties of layer 2/3 pyramidal cells in th

Our understanding of how developmental cell death contributes to the formation of brain circuits remains limited. Cajal-Retzius cells (CRs) constitute a major transient neuronal population in the mammalian neocortex, which largely disappears at the time of postnatal somatosensory maturation. In this study, we used mouse genetics, anatomical, functional and behavioral approaches to explore the impact of the early postnatal death of CRs in the maturation of the cortical circuit. We find that CRs apoptosis plays a crucial role in facilitating the proper development of inhibitory connectivity from