Topic: LC-NE neurons

Major depression is a psychiatric disease extremely widespread and the leading cause of disability worldwide. Child abuse, defined as physical, emotional and/or sexual abuse or neglect, is considered as one of the strongest predictors of depression and suicidal behaviors. While the role of the locus-coeruleus noradrenergic system (LC-NE) in the long term effect of early life stress induced depression has been demonstrated in male, its involvement in female is lacking. The aim of this project is to better understand the contribution of LC-NE circuits in early life stress-induced depression in a

While the interconnection of monoaminergic nuclei, namely the Raphe nucleus, Locus coeruleus (LC) and Ventral Tegmental Area (VTA) is widely acknowledged for its pivotal role in mediating diverse cerebral functions, the true complexity lies in the nuanced neuroanatomical and neurochemical diversity within each system. Recent discoveries have brought to light distinctive neuronal populations within the raphe nucleus or the LC, both projecting specifically to the VTA, main nucleus for dopamine secretion. The raphe nucleus is a neurochemically diverse hub, hosting not only serotonergic neurons bu