Combine complementary omics measurements to identify biological pathways and model cellular behaviour. Lectures and practicals compare supervised feature selection and integration using LASSO, PLS, LDA, mixOmics and DIABLO with unsupervised MOFA models and deep-learning autoencoders. The final day covers dimensionality reduction, graph-based integration, batch correction and multimodal single-cell analysis using Seurat and weighted nearest neighbours. Participants learn to select and implement an integration strategy suited to their research question. Live online, 15–17 February, 14:00–19:00
In Computer Science and Machine Learning
Seminar · Biomedical Engineering
NMC4 Short Talk: Decoding finger movements from human posterior parietal cortex
Charles Guan · California Institute of Technology
Wed, Dec 1, 2021 · 13:15 UTC
Restoring hand function is a top priority for individuals with tetraplegia. This challenge motivates considerable research on brain-computer interfaces (BCIs), which bypass damaged neural pathways to control paralyzed or prosthetic limbs. Here, we demonstrate the BCI control of a prosthetic hand using intracortical recordings from the posterior parietal cortex (PPC). As part of an ongoing clinical trial, two participants with cervical spinal cord injury were each implanted with a 96-channel array in the left PPC. Across four sessions each, we recorded neural activity while they attempted to pr