Topic: lentiviral delivery

ePoster: 2 ePosters

Oncogenic activation in glutamatergic progenitors leads to the formation of tumourspheres showing medulloblastoma Group 4-like features

Ana Lucia Rebelo, Angelina Sanderson, Raquel Soares, Adriana Sánchez-Danés · FENS Forum 2024

Medulloblastoma (MB) is an embryonal tumour that arises in the posterior fossa, being the most common malignant paediatric brain tumour. Currently there are four subgroups of medulloblastoma described, which arise from the alteration of specific neuronal stem or progenitor cell populations in exact spatio-temporal patterns(1). Group 4 MB (G4MB) is the most common subgroup of MB and has recently been described to arise from the failure of developmental processes in the differentiation of the rhombic lip (RL), implicating glutamatergic progenitors as putative cells of origin (2). Such cells orig

ePoster · Neuroscience

In vitro and in vivo targeting of amyloid-beta oligomers through intrabodies: Towards an innovative gene immunotherapy for Alzheimer’s disease

Laura Coppola, Raffaella Scardigli, Elena Fiori, Sofia Mancini, Silvia Middei, Federico La Regina, Giovanni Meli, Antonino Cattaneo · FENS Forum 2024

Aim: Decrease in adult neurogenesis has been described to correlate with Alzheimer’s disease (AD) progression, and we have previously demonstrated a causal link between Amyloid-beta oligomers (AβOs) accumulation in adult neural stem cells (NSCs) and reduced subventricular zone (SVZ) neurogenesis in AD Tg2576 mouse model at pre-symptomatic stage. Here we investigated if AβOs targeting in the dentate gyrus of AD mice, both at pre-symptomatic and symptomatic stage, can rescue adult hippocampal neurogenesis (AHN) and recover AD-related memory deficits. Methods: Using a disease modifying gene-thera

ePoster · Neuroscience