Topic: lentiviral vector

Cognitive functions like learning and memory depend on the time of day in various organisms. We have demonstrated that long-term recognition memory performance revealed an apparent diurnal/circadian change with the peak during the early night in nocturnal mice. SCOP (PHLPP1b) is a key molecule regulating hippocampus-dependent long-term memory in mice. The amounts of SCOP in the hippocampus exhibit robust circadian changes. Long-term memory formation in recognition memory is regulated by the circadian clock through SCOP dynamics in the hippocampal CA1 in nocturnal mice. Whether diurnal changes

Age-related neurodegenerative diseases are becoming more prevalent as human lifespan increases. Modeling human aging is challenging in the lab. We use transdifferentiation via an all-in-one lentiviral vector to directly reprogram human donor-derived fibroblasts into induced neurons (iN). The advantage of this methodology is the maintaining of age and disease-related signatures of the donor cells as iNs bypass the intermediary cell rejuvenation.Huntington’s disease (HD) is an autosomal dominant age-related neurodegenerative disorder caused by a mutated Huntingtin (HTT) gene containing an expans