Unraveling the “metabolic syndrome and cognitive decline” detrimental loop: What role for Mediterranean phytonutrients?
Giuditta Gambino, Danila Di Majo, Nicolò Ricciardi, Valentina Di Liberto, Roelof Maarten van Dijk, Mario Allegra, Giuseppe Ferraro, Pierangelo Sardo, Giuseppe Giglia · FENS Forum 2024
Metabolic Syndrome (MetS) and obesity correlate with cognitive impairment, heightening the susceptibility to cognitive decline and dementia. Noteworthy, cognitive impairment exacerbates weight management challenges in MetS, giving rise to a "cognitive decline-MetS" loop. Indeed, various cognitive and affective functions, including memory and executive functions, were found to be compromised in MetS, with underlying mechanistic pathways supporting a potential role of oxy-inflammatory signaling.Our research delves into the nuanced realm of cognitive alterations in MetS by examining the correlati