Topic: Lin28A

Embryonal Tumors with Multilayered Rosettes (ETMR) are a diverse and rare, but highly aggressive, form of embryonal brain tumors. All ETMRs share common histological and transcriptomic traits such as the presence of highly proliferative rosettes and aberrations on relevant miRNAs signaling pathways, including depletion of let-7 family miRNAs and increased Lin28A expression. Two different genetic alterations have been found to underlie ETMR tumors: amplification of the C19MC microRNA cluster, and biallelic Dicer1 inactivating mutations. Remarkably, a faithful animal model recapitulating this pa

LIN28A is an RNA-binding protein and stem cell marker, and its overexpression was described in rare malignant brain tumours of early childhood. CTNNB1 is an effector of the WNT pathway which plays important roles during development and activating mutations have been reported in malignant brain tumours. In order to investigate the interplay of these oncogenic proteins during embryonal brain development, we overexpressed both in murine neural progenitor cells in vivo.The sole overexpression of either LIN28A, stabilized Ctnnb1 or the combination of both in hGFAP-positive forebrain precursor cells