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Topic: lindane

ePoster
2 ePosters

In Neuroscience

ePoster · Neuroscience

Ferulic acid supplementation ameliorates lindane neurotoxicity: The effects on anxiety-like behavior

Dragan Hrnčić, Nikola Šutulović, Vladimir Bošković, Mladen Mirković, Milena Vesković, Dušan Mladenović, Yavuz Dodurga, Mucahit Seçme, Nebojša Radunović, Djuro Macut, Aleksandra Rašić-Marković, Olivera Stanojlović · FENS Forum 2024

Lindane is organochloride environmentally persistent pollutant used manly as pesticide. Neurotoxicity of lindane is manifested through cellular and behavioral changes including expression of anxiety, seizures and lethal outcome in higher doses. Ferulic acid is polyphenol organic compound with antioxidant and anti-inflammatory effects in different tissues including neuroprotective effects in acute and chronic application. We hypothesized that it could ameliorate some of the lindane neurotoxic effects. Therefore, we investigated the effects of ferulic acid chronic supplementation on anxiety-like

ePoster · Neuroscience

Lindane toxicity amelioration by delta sleep peptide supplementation: Advanced EEG study

Olivera Stanojlovic, Nikola Šutulović, Željko Grubač, Milena Vesković, Dušan Mladenović, Yavuz Dodurga, Mucahit Seçme, Djuro Macut, Nebojša Radunović, Aleksandra Rašić-Marković, Dragan Hrnčić · FENS Forum 2024

Lindane, gamma hexachlorocyclohexane is organochlorine compound that is environmental pollutant and is used as a pesticide and scabicide even today in a number of undeveloped countries. Lindane induces seizures refractory to conventional antiepileptics. Delta sleep-inducing peptide (DSIP) is an endogenous peptide that is constantly present in several different brain regions showing neuroprotective The aim of our study was to examine the effects of DSIP supplementation on electroencephalographic (EEG) ictal activity induced by lindane in rats. Adult male rats with previously implanted electrode