Topic: lineage tracing

Adult neurogenesis, the process by which new neurons are generated in the adult brain, is a complex phenomenon with implications for brain development and plasticity throughout life. Adult mice and rats present neurogenic niches in the dentate gyrus of the hippocampus, which produce new granular neurons. Acomys cahirinusis a new mammalian regeneration model that features extraordinary regenerative abilities, including full section of injured spinal cord. Adult neurogenesis and how it potentially contributes to brain repair in A. cahirinus has not been addressed. Transgenic Cre recombinase-expr

The superior colliculus (SC) is a dorsal midbrain structure known for its roles in multisensory integration and motor responses and its dysfunction has been linked to neurodevelopmental diseases. SC is a highly organized structure composed of distinct laminae of diverse neuronal and glial cell types. However, the precise developmental principles instructing the generation of SC cell-type diversity are still unknown. To investigate this, we pursued lineage tracing using genetic MADM (Mosaic Analysis with Double Markers)-based clonal analysis with single cell sequencing (MADM-CloneSeq) and in si