Topic: linear silicon probes

The rodent medial prefrontal cortex (mPFC) is considered central in executive functioning and decision making, and from an anatomical perspective there is consensus that the mPFC is not a single homogenous structure. However, the nature of mPFC is more contentious in the functional domain, with disagreement as to whether mPFC is homogenous, or instead composed of multiple distinct subregions with distinct roles. To answer this question it is necessary to monitor activity across a wide swath of mPFC as rats actively engage prefrontal processing, and critically, to precisely identify the anatomi

Neurons in sensory areas are tuned to various input features, and tuning properties reveal essential aspects of the computation performed by the neuronal population. In the post-subiculum (PoSub), neurons are modulated by the animal’s head-direction (HD), and most pyramidal neurons are fine tuned to a specific direction. Other cell types, especially fast-spiking neurons, are less specifically tuned but are generally still modulated by HD. By recording from ensembles of neurons in the PoSub in freely moving mice with linear silicon probes, making it possible to determine precise anatomical loca