Topic: lipofuscin

Our environment is polluted with plastic waste, wherein the degradation leads to the formation of micro and nanoplastics (NPs). These plastic particles contaminate water, soil, air, and food, exposing humans throughout their lives. Although NPs are detected in the human body, such as in blood, feces, and placenta, their potential impact on human health remains poorly understood. Moreover, the developing brains of fetuses and children may be sensitive to these molecules, potentially leading to functional impairments and altered behavior. Our study investigates the impact of chronic, low-dose ex

Lipofuscin is an autofluorescent storage material that accumulates in the brain with normal aging. Lipofuscin deposition is also observed in numerous disease states but is most profound in neuronal ceroid lipofuscinoses (NCLs), a group of fatal neurodegenerative disorders that primarily affect children. Lipofuscin is known to be generally composed of proteins, lipids, metals, and carbohydrates, yet few specific lipofuscin constituents have been elucidated. Further, the spatiotemporal progression of lipofuscin accumulation in murine models remains unclear. An improved molecular and neuroanatomi

Microglia, as macrophages in the brain, exhibit dysfunction with aging, such as impaired phagocytic capability and elevated neuroinflammation. However, the mechanisms underlying microglial aging remain unclear. The heterogeneity of microglia further challenges this context. Disrupted-in-schizophrenia 1 (DISC1), a psychiatric disorder susceptibility gene disrupted by translocation, plays an essential role in regulating the development and function of neurons. We observe that DISC1 is also expressed in microglia, where it exhibits an aggregates-like pattern (Figure A). We called this population