Topic: LipoStatin

We investigated whether a synergistic effect would emerge in post-stroke treatment by opening the blood-brain barrier (BBB) with focused magnetic stimulation (MagStim) and delivering Atorvastatin-Loaded PEGylated Liposomes (LipoStatin). Two weeks after middle cerebral artery occlusion (MCAO), magnetic nanoparticles (MNP) were injected at a concentration of 15mg/ml, followed by 30 minutes of MagStim. The procedure was conducted over a week with MagStim, and magnetic nanoparticles (MNP) were injected three times at two-day intervals. After MagStim, LipoStatin at 10mg/kg was administered intraven

Insufficient evidence exists regarding the effect of nanoparticles, particularly liposomes loaded with a statin, on traumatic brain injury (TBI). We investigated the impact of atorvastatin-loaded PEG (polyethylene glycol) conjugated liposomes (LipoStatin) on outcomes in mice with TBI. PEGylated liposomes loaded with atorvastatin were developed as nanoparticles to specifically accumulate in the injury region and release the drug to lessen the harmful effects of TBI. TBI was induced using the Marmarou method, applying five consecutive head impacts at 12-hour intervals with a weight of 120 g for