Topic: liraglutide

Metabolic Associated Fatty Liver Disease (MAFLD) has recently emerged as a major health concern in Western countries, being characterized by hepatic fat accumulation, altered metabolism, increased oxidative stress, and inflammation. This condition triggers the release of hormones, free radicals, and inflammatory mediators in blood, potentially affecting central nervous system. Unfortunately, limited studies have explored the impact of MAFLD on the brain and its potential association with neuronal metabolism and activity. In our study, we utilized preclinical MAFLD model induced by a six-week e

Liraglutide and other agonists of the glucagon-like peptide 1 receptor (GLP-1RAs) are effective weight loss drugs, but how they suppress appetite remains unclear. GLP-1RAs inhibit hunger-promoting Agouti-related peptide (AgRP) neurons of the arcuate hypothalamus (Arc) but only indirectly, implicating synaptic afferents to AgRP neurons. To investigate, we developed a new method combining monosynaptic rabies with single-cell transcriptomics to identify connected neurons in a genetically tractable manner: “RAMPANT” (Rabies Afferent Mapping by Poly-A Nuclear Transcriptomics). Applying RAMPANT to A