Topic: Live Mouse Tracker

Aggression and substance use disorders (SUDs) show consistent associations, although their causal link remains to be understood. Human genetic studies have identified an association between a single nucleotide polymorphism (rs16969968) of the CHRNA5 gene encoding the α5 subunit of the nicotinic acetylcholine receptors (nAChRs) (α5SNP) and higher scores of nicotine dependence. We and others have shown that the α5SNP is associated with a loss of function of α5 containing nAChRs (α5*nAChRs) and strongly modulates addiction-like behaviors in response not only to nicotine but also to alcohol and co

Approximately 2-5% of pregnant women may use cannabidiol (CBD) on a weekly basis: an estimated 75,000 to 200,000 fetuses annually in the US alone are exposed to CBD. Identifying the impact of CBD on the developing CNS is a public health priority. CBD crosses the placenta and concentrate in breast milk. To investigate the long-term behavioral consequences of fetal CBD exposure, we compared the behavior of adult offspring from dams exposed daily to a low dose of CBD (3mg/kg s.c., E5-E18). The adult offspring was observed using Live Mouse Tracker, a methodology, based on deep learning, eliminatin