ePoster · Pathophysiology
Liver, kidney, and spleen as Aβ scavenger systems in Alzheimer’s disease and the impact of social isolation in normal and pathological aging
Juan Fraile-Ramos, Josep Reig-Vilallonga, Lydia Giménez-Llort · FENS Forum 2024
The liver, responsible for regulating the metabolism of the body; the kidney, the most important organ for waste elimination, and the spleen, in charge of filtering the blood and producing lymphocytes, are now considered to have clearance functions in Alzheimer’s disease (AD) eliminating Aβ from the brain. In the present work, we used different levels of study to examine the status and involvement of these three organs in 16-months-old male and female 3xTg-AD for AD and compared them to C57BL/6 counterparts with physiological aging, in two different social scenarios. All three organs presented