Topic: local inhibition

It is beyond doubt that cognitive phenomena such as language and reasoning are the direct product of the activity of neurons and synapses. Making progress on this open question, often called the bridging problem, was identified by Richard Axel as the most important challenge in neuroscience today. The research community must identify, from among the ever growing volume of neuroscientific knowledge a conceptual core of basic elements and principles which may suffice for bringing about the brain’s function. Here we describe such a minimalistic model of the brain, and we demonstrate its power by

Neuropathic pain is evoked by an injury to the somatosensory system at the peripheral or central nervous system level leading to direct changes in neuronal activity. Moreover, there is a large body of evidence that changes occurring in primary peripheral sensory neurons also alter secondary central circuits thus causing hyperalgesia and allodynia. The latter are hallmarks of neuropathic pain and recent work suggests that both of those sensory abnormalities depend on alterations in spinal dorsal horn circuits likely caused by a loss of local inhibition. However, the molecular mechanisms that le