Topic: local protein synthesis

Neurons use a variety of strategies, including local protein synthesis and pre-established protein pools inside dendrites, to maintain the dynamic proteome requirements for appropriate synaptic activity. While certain proteins have local mRNA that allows for on-demand synthesis at the synapse, the vast majority do not. This poses an important question: how can these proteins manage their copy number without boosting the synthesis rate locally? This study looks into the hypothesis that the amount of the protein pool in dendrites corresponds with the presence or lack of dendritic mRNA for local

Understanding how neurons regulate their protein composition to refine synaptic connections across millimeters of space provides critical insights into the mechanisms of synaptic plasticity. The discovery of local protein synthesis in subcellular compartments has shown how neuronal activity can locally meet the metabolic demands of synaptic plasticity$^{1,2}$. Despite the experimental challenges posed by the long and complex branches of axons, the presence of mRNA and local protein synthesis in presynaptic boutons has been clearly demonstrated$^{3,5}$. In this study, we developed an in silico