Topic: Long-Evans rats

Animal models of neurovascular uncoupling (NVU) would be important tools for developing drugs in neurodegenerative disorders. Pharmacologically induced NVU was established in mice [Tarantini et al., 2015] but only preliminary results are available in rats [Varga et al., 2022]. In the current study we attempted to evoke NVU in a translationally relevant rat population.We used 28-month-old male Long-Evans rats with learning history and stable performance in 5-choice serial reaction time task (5-CSRTT). Morris water-maze (MWM), pot jumping, and touchscreen pairwise discrimination. NVU was induced

Object vision relies on the ability to tolerate identity-preserving transformations, such as scaling, translation, and rotation of visual objects. Even larger transformations can be achieved when a visual pattern emerges from second-order (texture) cues or by configural arrangements of local features constructing a global (Gestalt) figure. While humans generalize across such transformations, it remains unclear whether lower mammals, such as rodents, share with us this ability. Recent studies have shown that rats can recognize objects despite identity-preserving transformations, but little is k

Sleep-wake disturbances are common in sepsis. We previously hypothesized in an anaesthetized sepsis model, that acute changes in sleep-state dynamics were linked to altered in attractor state dynamics. Here, we studied the acute effects of high-dose LPS injection (5mg/kg) on brain activity in a non-anaesthetized survival model.LFP was recorded from dorsal hippocampus and overlaying cortex of 13 male Long-Evans rats before and after LPS injection. Sleep-wake states were scored for cortex and hippocampus, and analyzed using a 3-D power-spectrum-based state-space approach. Additionally, aperiodic