Topic: long-term depression (LTD)

The metabotropic glutamate receptor, mGlu5, plays a critical role in the persistency of hippocampal long-term potentiation (LTP), long-term depression (LTD) as well as hippocampus-dependent associative learning and memory (doi: 10.3390/cells11213352). Although well-studied, the majority of investigations as to the role of mGlu5 in these processes in rodents has been done during the light cycle that amounts to the resting phase of rodent species. Sleep-states are regulated by mGlu5 (doi: 10.3390/cells12131761) suggesting that its contribution to hippocampal information processing and storage ma

The retrosplenial cortex (RSC) and hippocampus support the encoding, storage, and retrieval of different aspects of associative experience. In the hippocampus, learning and updating information about the content details of space triggers long-term depression (LTD) (doi: 10.3389/fnbeh.2022.806356) . Here we used fluorescence in situ hybridization (FISH) explore to what extent this kind of spatial content learning triggers somatic immediate early gene (IEG i.e. Homer1a) expression in the cornus ammonis and RSC, as an indication of active storage of learned experience. Adult rats explored novel s

Long-term depression (LTD) is an activity-dependent decrease of synaptic strength. This depressed state is transient, initiating either a re-potentiation or suppression, referred to as pruning, of the synapse within hours to days following the LTD induction. Nevertheless, the precise relationship between LTD and synaptic pruning remains incompletely elucidated. Through the integration of various imaging techniques and electrophysiology, we have identified essential factors that link NMDAR-dependent LTD to synaptic pruning. The molecular alterations pivotal for the induction of LTD must persist