Topic: long-term memory consolidation

Growth Arrest and DNA Damage inducible protein 45 alpha (Gadd45ɑ) is a protein well characterised for its role in DNA demethylation and cell cycle regulation. Behavioural studies showed that Gadd45ɑ-knock-out (KO) in mice impairs long-term memory consolidation following aversive learning tests. Proceeding experiments revealed that Gadd45ɑ is an RNA binding protein (RBP) that post-transcriptionally stabilises synaptic plasticity- and memory-related mRNAs in an activity-dependent manner. This project aims to decode the RNA and protein interaction networks of Gadd45ɑ in mouse hippocampal cells.Me

Neurons are highly plastic cells, altering the proteome to adapt to environmental cues. These changes are governed by fluctuations in protein synthesis pace and the nature of the mRNAs that are being translated. Although it is well established that de novo protein synthesis is fundamental to consolidate long-term memory, many details remain unknown, including the molecular mechanisms that trigger protein synthesis pace elevation that drive consolidation. Mounting evidence suggests that triggering long-term memory consolidation requires the release of the translation initiation brake, particula

The medial prefrontal cortex (mPFC) has a broad role in cognitive flexibility and executive function, as well as long-term memory consolidation. These distinct functions are reconciled by the mPFC’s role in context-dependent decision making, which requires the evaluation and selection of representations that are relevant for a particular goal.The hippocampus and mPFC interact via direct and indirect pathways. Coordinated activity between these regions occurs both during hippocampal theta and sharp-wave ripples (SWRs) and is correlated with performance during tasks that rely on spatial informat