Topic: long-term potentiation (LTP)

BDNF mediates long-term potentiation (LTP) of hippocampal CA1 synapses by a translation-dependent mechanism. A master regulator of local protein synthesis at the synapse is fragile-X-messenger ribonucleoprotein (FMRP), however it is unclear to what extent FMRP mediates the effects of BDNF on the synaptic proteome. In this work we investigated whether FMRP regulates the synaptic content of GluN2B-containing NMDA receptors (NMDAR) with implication in synaptic plasticity. Acute hippocampal slices were prepared from WT and Fmr1y/- mice, and LTP was triggered with five theta-bursts, which induces B