ePoster · Molecular Neuroscience
Hyperlipidemia does not suppress mitophagy in the hippocampus
Naz Mengi Camur, Busranur Seker, Fulya Kizildag, Umut Inci Onat, Tulin Yanik, Michelle Adams · FENS Forum 2024
Hyperlipidemia is a risk factor for developing atherosclerosis and neurodegenerative disorders, however the underlying molecular mechanisms are not well understood. Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK) signaling is one of the molecular pathways thought to be involved in hyperlipidemia-driven neurodegeneration. Studies indicate that mitophagy, regulated by phosphatase tension homolog-induced kinase-1 (PINK1) and Parkin, is crucial for removing damaged mitochondria; otherwise, this can lead to disrupted mitochondrial function. Increased cholesterol levels impair mitophagy in