Topic: lumbar spinal cord

The clinical challenge posed by spinal cord injury (SCI) remains a significant and unresolved issue. Engineering a treatment for SCI will require biological repair interventions that restore connectivity through or around lesions. Using a combination of advanced neuroanatomical viral tract tracing, projection-specific and comparative single-nucleus RNA sequencing, bioinformatic techniques, we recently identified a molecularly defined subpopulation of excitatory projection neuron in the mid-thoracic spinal cord that extend axons to the lumbar spinal cord where walking execution centers reside.

Aims: Plastic changes of neurons in spinal cord after peripheral nerve injury remain to be elucidated. The aim of this research is to clarify plastic changes of neurons and pericellular synapses in lumbar spinal cord after sciatic nerve transection.Methods: Neurons and pericellular synapses in lumbar spinal cord of rats were analyzed 6 weeks after sciatic nerve transection. The axonal volume of cortical neurons was labeled with biotinylated dextran amine, the volume of motoneuron soma with Fluoro-Gold, cholinergic interneurons with vAchT, and pericellular synapses with vGlut1 and vAchT. They w

Transcranial static magnetic field stimulation (tSMS) utilizing a small and strong neodymium (NdFeB) magnet is a non-invasive brain stimulation method with advantages of the safety, simplicity, and inexpensiveness. While tSMS has demonstrated the ability to suppress brain functions below the magnet, the neuromodulatory effects on the spinal cord remain unclear. This study aimed to investigate the neuromodulatory effects of tSMS on the lumbar spinal cord. We applied tSMS over the lumbar spinal cord for 20 min in 15 healthy subjects. The H reflex, served as an index of excitability in the lumbar