Topic: macroautophagy

Aging drives cognitive decline in the adult brain with unclear mechanisms. Previously, oligodendrocyte precursor cells (OPCs), the source cells of myelin-forming cells in the central nervous system (CNS), have been linked to brain aging by their compromised differentiation and regeneration capability. Whether a myelination-independent function of OPCs is involved in brain aging remains unknown. In this study, we herein report a novel role of OPCs in brain aging via disrupting neuronal plasticity. Our results demonstrate that macroautophagy influx declines in aged OPCs, which results in the acc

Aims: Mitochondrial damage is neutralised by mitophagy, thereby preventing cellular dysfunction and apoptosis. Mitophagy is the selective autophagy of mitochondria and has long been linked to age-dependent neurodegenerative disorders, including Parkinson’s and Alzheimer’s disease. . In cell-based systems and short-lived model organisms, mitophagy declines with age. However, the trajectories of mitophagy within the aging mammalian brain remain unexplored. We profiled mitophagy and macroautophagy within intact brain tissues using advanced genetically-encoded optical reporter mice. Methods: We an