Topic: MAGIC Markers

Astrocytes constitute a heterogeneous population of cells in terms of function and morphology. Although several embryonic sources of cortical astrocytes have been reported, cortical progenitors located from the dorsal pallium are considered their main production site. However, the potential link between the heterogeneity of cortical astrocytes and their developmental origin remains elusive. Recently, we identified a new embryonic source for cortical protoplasmic astrocytes located outside of the dorsal pallium, in a restricted domain containing Aldh1L1-expressing cells. In order to further cha

Autism Spectrum Disorders (ASD) is a multifactorial neurodevelopmental pathology, resulting from a combination of genetic and environmental factors. However, the contribution of each of these two components to the onset and/or the evolution of ASD remains undetermined. Hence the aim of our research project is to evaluate the impact of an in utero exposure to a cocktail of fungicide residues at a European regulatory dose on the brain development of a well-established ASD model, the CNTNAP2 gene-deficient mouse. In order to determine whether the chronic exposure to fungicide might increase the s