Major depression

…circuits implicated in anxiety and depression. The session examines stress-related disruption of neuroimmune communication, including inflammation and increased monocyte abundance. It connects these mechanisms with translational efforts to develop targeted interventions for major depression and post-traumatic stress disorder.

…been linked with increased risk for major depression and anxiety disorders. Nevertheless, not all individuals exposed to strong stressful events develop psychopathology, with the mechanisms of resilience

…promising preliminary outcomes in major depression, making them interesting candidates for clinical practice. Despite several promising clinical studies, the influence of the context on therapeutic responses or adverse effects remains poorly documented. To address this, we conducted preclinical studies evaluating the psychopharmacological profile of 5-MeO-DMT in contexts previously validated in mice as

…of psychiatric diseases such as major depression, bipolar disorder and schizophrenia. These deficits have been linked to the dysfunction of the mesocorticolimbic dopamine transmission suggesting the existence of common underlying pathophysiological mechanisms. Numerous clinical studies have described a decrease in n-3 polyunsaturated fatty acids (PUFAs) in subpopulations of patients suffering from psychiatric disorders (Conklin et al., 2010; Messamore and McNamara, 2016). Moreover, preclinical results from our laboratory

Major depression is a psychiatric disease extremely widespread and the leading cause of disability worldwide. Child abuse, defined as physical, emotional and/or sexual abuse or neglect, is considered as one of the strongest predictors of depression and suicidal behaviors. While the role of the locus-coeruleus noradrenergic system (LC-NE) in the long term effect of early life stress induced depression has been demonstrated in male, its involvement in female is lacking. The aim of this project is to better understand the contribution of LC-NE circuits in early life stress-induced depression in a