Topic: male mice

Early stress episodes affect brain development and is related to increased risk of developing stress-induced depression in adulthood. However, little is known about the sexual differences in this process. Our goal is to study how stress in different developmental periods affects depression-like behaviours in male and female mice. For this purpose, four experimental groups of both male and female mice of strain C57BL/6J were used: control (C) Juvenile (JE), adult (AE), and double stress JE+AE (DE).Depression-like behaviours were evaluated in the adult period. Nest building test was used to asse

Brain oscillations, whether spontaneous or evoked, may serve as biomarkers for diagnosing or even predicting psychiatric disorders (Mathalon and Sohal, 2015). The state of brain oscillations is believed to reflect the balance between excitation and inhibition in neural networks (Kim et al., 2015). As neurotransmission is significantly influenced by sex hormones (Krolick et al., 2018), it is reasonable to expect sex differences in brain oscillations between males and females. However, there is a lack of data, particularly in the field of animal research (Shansky and Murphy, 2021). Therefore, in