Topic: mammalian cells

A January–June 2027 placement developing and optimising gene editing systems for therapeutic programmes. Work includes generating reagents and small-scale mRNA preparations, maintaining mammalian cells, transfecting cells, isolating genomic DNA and preparing samples for sequencing. The student collaborates with research scientists on experimental design, data interpretation and presentations. The position is based in Cambridge, Massachusetts.

While the motion and collective behavior of cells are well-studied on flat surfaces or in unconfined liquid media, in most natural settings, cells thrive in complex 3D environments. Bioprinting processes are capable of structuring cells in 3D and conventional bioprinting approaches address this challenge by embedding cells in bio-degradable polymer networks. However, heterogeneity in network structure and biodegradation often preclude quantitative studies of cell behavior in specified 3D architectures. Here, I will present a new approach to 3D bioprinting of cellular communities that utilizes