Topic: manifold learning

Brain stimulation is a fundamental therapy for neurological diseases including Parkinson’s disease, essential tremor, and epilepsy. One key challenge in delivering effective brain stimulation is identifying the stimulation parameters (e.g. amplitude, frequency, and pulse width) that optimally change symptoms, behavior, or neural activity. Most clinical and translational studies use constant-frequency pulses of stimulation, but irregular pulse patterns or non-pulsatile waveforms may induce unique neural effects that could enable better therapy. Here, we comprehensively evaluate several optogene