Topic: MAP1B

Periventricular heterotopia (PH) is a cortical malformation characterized by misplaced neurons adjacent to the lateral ventricles, commonly associated with epilepsy. It is genetically diverse, and its underlying mechanisms are not fully understood. While recent research suggests that neuronal differentiation can also be affected, it has traditionally been considered a neuronal migration disorder, supported by the identification of mutations in neuronal-enriched cytoskeletal genes. Furthermore, it is still unclear why only some neurons are affected in this condition, while the majority of other

Restoring the regenerative capacity of adult neurons after spinal cord injury has been an important challenge of the past decades. Unlike the peripheral branch of the nervous system, CNS axons fail to regenerate following injury. This inability has a two-fold origin, a neuron-extrinsic and -intrinsic one. The former has been well described in literature and is related to the inhibitory effect of the CNS environment on outgrowth of adult neurites. The latter has been attributed to the cellular makeup of adult neurons which is primed toward synaptic maturity and functionality, as opposed to rege