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Topic: MAP2

ePoster
2 ePosters

In Neuroscience

Activation of non-nuclear estrogen receptor signaling pathways with PaPE-1 as a potential remedy for amyloid-beta induced toxicity: Impact on autophagy

Bernadeta Pietrzak-Wawrzyńska, Agnieszka Wnuk, Karolina Przepiórska-Drońska, Andrzej Łach, Małgorzata Kajta · FENS Forum 2024

Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by extracellular accumulation of amyloid-beta. Estrogen receptors (ERs) are widely recognized as mediators of neuroprotection from various insults. Recent research has highlighted the distinction between nuclear and non-nuclear ER activation mechanisms, positioning non-nuclear ERs as a safer option, devoid of the cardiovascular and cancer risks associated with nuclear ER activation. In this study, we aimed to confirm the neuroprotective potential of PaPE-1, a novel compound that preferentially activates non-nuc

ePoster · Neuroscience

SH-SY5Y cell differentiation to dopaminergic neuron-like cells using retinoic acid

Simas Janutenas, Vassileios Stratoulias, Umamaheswari Umasankar, Silvia Orsini · FENS Forum 2024

Background: We study dopaminergic neurons with specific emphasis on Parkinson’s disease. Our work involves implementing procedures for examining in vitro mouse primary dopaminergic neurons as well as dopaminergic neurons derived from human stem cells. Here we want to establish a continuous cell line model for fast and cost-effective production of human dopaminergic-like cells to be used in our studies. Aims: Differentiate SH-SY5Y cells into dopaminergic-like cells using Retinoic Acid. Optimize the differentiation protocol for highest yield of TH positive cells. Methods: Retinoic Acid is used t

ePoster · Neuroscience