Topic: MAPK

Introduction: Epileptogenesis is the molecular and cellular process by which a healthy brain becomes an epileptic one. Some evidence suggests that the disruption of circadian rhythms may be impacting the epilepsy phenotype. However, whether the molecular clock is a key player in epileptogenesis remains to be elucidated. Here, we mapped for the first-time the hippocampal molecular rhythmicity of mice during epileptogenesis. Methods: Male adult C57BL/6 mice (n=5/group/Zeitgeber-Times [ZTs]) underwent intra-amygdala kainic acid-induced (i.a.KA) status epilepticus or control (i.a.PBS). From 24h af

Platelet activation plays a crucial role in cerebral vascular diseases (CVDs) such as ischemic stroke, making the suppression of platelet function a promising strategy for mitigating CVDs. Ginkgetin (GK), from Ginkgo biloba L, known for its diverse bioactivities, remains largely unexplored in modulating platelet activity. This study systematically investigated GK's effects on human platelets, aiming to understand its therapeutic potential in alleviating CVDs. The experiments examined GK's effects on human platelets, analyzing aggregation, secretion, calcium mobilization, and thromboxane genera