Topic: maternal depression

Maternal depression presents risks to both fetal and child development. While treating maternal depression with antidepressants during pregnancy can alleviate the condition, it also has implications for the development of the offspring. Our study aims to explore the impact of maternal depression and/or prenatal antidepressant treatment on offspring neuronal excitability.We implemented an animal model of maternal depression through chronic and unpredictable stress exposure. Mirtazapine served as the chosen antidepressant. Four experimental groups were used: no stress with vehicle, stress with v

Computational models play a key role in elucidating the complex behaviour of neurons. However, many of these models are tuned to the electrophysiological features of adult neurons, leaving a significant gap in the modelling of immature perinatal neurons. This study aims to bridge this gap by generating a population of computational models representing hippocampal neurons from primary hippocampal cultures of neonatal rat brains and comparing them with models of adult neurons in terms of variability in ion channels and electrophysiological behaviour. Using the TREES toolbox, we reconstructed the