Mathematical simulations

…Integrate quantitative imaging with mathematical simulations, collaborate with experimentalists and contribute to open-source tools and teaching. This salaried doctoral position is based in Basel and accepts applications on a rolling basis until filled. Apply through the ETH online recruitment portal.

Microglia,the resident macrophages of the brain,originate from yolk sac progenitors and invade the brain at embryonic stages to progressively become integrated in the parenchyma.However, the mechanisms driving the acquisition of the mature microglia phenotype during development are yet unclear.Our hypothesis is that the intrinsic genetic programs that establish the microglial identity early on are fine-tuned by the brain environment.To test this hypothesis,we focused on the hippocampus and the cerebellum,two structures with protracted development.We found that microglial development occurs in