Topic: MBP

Recent studies show that horizontal L2/3 axonal projections exhibit increased myelin segments elongation following monocular deprivation. Such adaptive myelin plasticity may improve synaptic efficacy of corticocortical connections with a possible role in mediating the reorganization of cortical maps after sensory deprivation. Here, we explored the relationship between axonal myelination and the level of cortical reorganization in distinct layers of the somatosensory cortex following central sensory deprivation. Complete thoracic spinal cord was used to induce sensory deprivation of the cortica

In human, genetic predispositions or deleterious environmental conditions may cause adverse effects on the developing brain. In preterm neonates, oligodendrocytes are particularly vulnerable and hypoxic conditions may result in white matter lesions leading to cerebral palsy and long-term disabilities. The glutamatergic transmission plays a critical role in the pathophysiology of these lesions but it is also a key actor involved in developmental mechanisms such as cell differentiation. Previous studies demonstrated a strong expression of the N-methyl-D-aspartate receptor by endothelial cells (e

The chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease affecting myelin and neural structures of the PNS. In recent studies, propionic acid (PA) showed anti-inflammatory and disease modifying effects in multiple sclerosis patients. Additionally, PA exerted neuroprotective and neuroregenerative effects in PNS in vitro cell cultures of Schwann cells (SC) and dorsal root ganglia (DRG). In this study, we investigate the potential effects of PA on SC derived from rats sciatic nerve. First, SC were treated with IFNγ to induce MHC-II receptor expression, which was measu

Oligodendrocytes (OLs) are the myelin-forming cells in the Central Nervous System of vertebrates. The role of Adenosine A2A receptors (A2ARs) and brain-derived neurotrophic factor (BDNF) on adult oligodendrogenesis from subventricular zone neural stem cells (SVZ-NSCs) remains highly unknown. We aimed at studying how these modulators and their putative crosstalk impact OL differentiation from postnatal SVZ-NSCs. For this, C57BL/6 P1-3 mice SVZ-derived neurospheres were pharmacologically exposed to BDNF (30 ng/mL) and ZM 241385 (50 nM), an antagonist for A2ARs. mRNA expression levels of oligoden