Topic: MC4R

Obesity, a widespread health issue, accompanied by various metabolism-related disabilities, has emerged as a significant public health challenge. Primary intervention for obesity involves lifestyle changes, including dietary treatments. The ketogenic diet (KD) is increasingly recognized as a potential remedy for obesity, with its efficacy attributed to appetite suppression in the hypothalamus.The study aimed to evaluate how the metabolic changes in hypothalamus, associated with obesity affect the mechanisms responsible for appetite regulation during KD treatment.Adult male mice were subjected

The melanocortin receptor subtype 4 (MC4R) is expressed in various human cells such as skin melanocytes, astrocytes, and neural progenitor cells1.Our aim is to evaluate the role of MCR4 as a novel target in melanoma therapy, using a selective antagonist ML00253764 (ML) alone and in combination with the B-Raf V600E inhibitor Vemurafenib.We employed the human melanoma B-Raf mutated A-2058 and WM 266-4 cell lines, while the CRISPR/Cas9 system was used to eliminate the MCR4 gene in the A-2058 cell line (MCR4 null).MC4R protein expression in melanoma cells was then tested though immunohistochemistr