Mechanoreceptors

…the heterogeneous population of mechanoreceptors that lies within the skin. In the whisker system this is achieved via three three types of mechanoreceptors (MR) in the whisker follicle: Slowly Adapting type 1 (SA1), Slowly Adapting type 2 (SA2), and Rapidly Adapting (RA) [1]. In this study, we aim to understand the role of these different types of MRs in stimulus representation. We fit Adaptive Ex

Introduction: Fibromyalgia syndrome (FMS) represents a complex and challenging condition characterized by widespread pain and an intricate interplay of genetic and environmental factors. Artificial intelligence (AI) offers the possibility of using previous knowledge to understand the molecular underpinnings of pain in FMS. The goal of this study was to leverage this information for drug repurposing prediction, setting the basis for new Clinical Trials. Methods: This study employed an innovative comprehensive approach utilizing AI for a systematic screening of genetic, clinical, and drug-relate

…that they are both low threshold mechanoreceptors but possess different adaptation properties. Lastly, genetic ablation of Prox2 and Runx3 neurons demonstrated their essential

…how information from a small number of mechanoreceptors on the wings are used in flight control. She employs a combination of experimental and computational techniques to study how these sensors respond during flight and how one might optimally array a set of these sensors to best provide feedback during flight.

The vagus nerve contains a diversity of sensory neurons that detect peripheral stimuli such as blood pressure changes at the aortic arch, lung expansion during breathing, meal-induced stomach distension, and chemotherapeutics that induce nausea. Underlying vagal sensory mechanisms are largely unresolved at a molecular level, presenting tremendously important problems in sensory biology. We charted vagal sensory neurons by single cell RNA sequencing, identifying novel cell surface receptors and classifying a staggering diversity of sensory neuron types. We then generated a collection of ires-Cr