Topic: membrane conductance

The onset of a stimulus, whether sensory or non-sensory, quenches trial-to-trial neural variability. The universality of this phenomenon across brain areas and species implies that it is a fundamental strategy employed by the brain to boost the fidelity of stimulus representation. Multiple network models have attempted to explain this phenomenon via circuit interactions, but a recent alternative theory proposes a much simpler cell-intrinsic mechanism: stimulus onset increases membrane conductance which itself is enough to quench output variability. Although this model can explain all of the ph

Glioblastoma (GBM) is the most malignant form of primary brain tumor. It is characterized by the presence of highly invasive cancer cells infiltrating the brain by interacting with astrocytes and endothelial cells. During invasion, GBM cells significantly shrink their volume and extend lamellipodia by modulating their membrane conductance repertoire. However, the changes in compartment-specific ionic dynamics involved in this process are still not fully understood. To investigate the alterations in the GBM cells membrane conductance during lamellipodia formation and migration, a battery of com