Topic: membrane contact sites

Form and function of neurons are intricately linked. Long axons reach far away targets and dendrites branch wide to integrate signals, allowing neurons to form an extremely dense network to process external stimuli. While we are gaining a better understanding of the rules of circuit wiring, at the intracellular level we still lack an understanding about which features are random, which are controlled organization and which are cell type specific. Reconstructions of the neuronal ultrastructure is a multiscale problem spanning from the few nm-scale of ER diameter to the dimension of cells and ne