Topic: memory loss

Obesity and metabolic disorders are linked with neurodegenerative diseases through persistent peripheral inflammation caused by metabolic alterations, which underlies chronic neuroinflammation. Pleiotrophin (PTN) is a cytokine that regulates neuroinflammation and metabolism in different contexts. Thus, our study aimed to determine the role of PTN in the brain-periphery crosstalk in a high-fat diet (HFD)-induced obesity model. Three-month-old C57BL/6J wild-type (Ptn+/+) and Ptn genetically deficient (Ptn−/−) mice were fed with standard chow diet or HFD (60% kcal fat) for 6 months. HFD-Ptn−/− mi

The loss of memories is the earliest and often most detrimental symptom in the course of Alzheimer’s disease (AD), the most common form of dementia. The loss of neuronal cells, which are assumed to carry mnemonic information, suggests itself to be the leading cause of memory loss. Besides, the question of alternative mechanisms has been raised. Our lab recently showed that an additional cell ensemble, so-called novelty-like cells, interfered with the engram and thus, impaired memory recall. This suggests a novel mechanism of memory impairment. However, the exact circuit that leads to the evoca