Topic: meninges

Globoid cell Leukodystrophy Disease (GLD) is a neurodegenerative life-threatening disease caused by genetic defects in the lysosomal enzyme galactosylceramidase (GALC). There is no cure for GLD. Treatment options are still very poor. Here, we consider GLD pathogenesis from an entirely new angle, changing the focus from the neurons and oligodendrocytes to the non-parenchymal brain cells. Meninges host neural stem/precursor cells with neuronal differentiation potential and are emerging as injury-induced site in many neurodegenerative diseases. To study the involvement of meninges in GLD pathogen

In this study, we aimed to elucidate the anatomical and ultrastructural characteristics of CNS border-associated macrophages (BAMs) in the context of ischemic stroke. At 7 days after ischemia, the number of BAMs, identified by the expression of CD206, Lyve1, and Iba1, increased compared to the contralateral cortex. They were primarily distributed along the meninges and PVS within the lesion core, while their presence within the extravascular parenchyma was limited. Notably, a subset of BAMs did not express Lyve1 in the meninges and PVS. The heterogeneity of BAMs based on their morphology and m

The meninges are a protective and nutritious tissue that surrounds the central nervous system (CNS) and supports the brain. Recent data, including from our team, have revealed that the meninges contain a myriad of immune cells, such as meningeal macrophages (MM). Interestingly, the meninges penetrate the brain parenchyma and contact sub-structures such as the hippocampus, which is one of the main neurogenic niches. This strategic position of the meninges and thus MM raised the hypothesis that these cells could play a role in hippocampal neonatal neurogenesis. To address this question, we used