Topic: Metaplastic priming

The medial (MPP) and lateral perforant path (LPP) inputs to the dentate gyrus (DG) comprise a prominent source of information for the hippocampus. Behavioral and anatomical studies have indicated that the MPP provides information about metric space and the LPP provides information about item identity to the hippocampus. This may influence how information is encoded in MPP and LPP inputs to the hippocampus.Here, we examined the frequency-dependency of synaptic plasticity in MPP-DG and LPP-DG synapses of the dorsal hippocampus of freely behaving adult male rats using patterned afferent stimulati

The metabotropic glutamate receptor, mGlu5, plays a critical role in the persistency of hippocampal long-term potentiation (LTP), long-term depression (LTD) as well as hippocampus-dependent associative learning and memory (doi: 10.3390/cells11213352). Although well-studied, the majority of investigations as to the role of mGlu5 in these processes in rodents has been done during the light cycle that amounts to the resting phase of rodent species. Sleep-states are regulated by mGlu5 (doi: 10.3390/cells12131761) suggesting that its contribution to hippocampal information processing and storage ma