Topic: Mfn2

Charcot Marie Tooth (CMT) disease is a rare and incurable genetic disease of the Peripheral Nervous System resulting from defects in Schwann cells (demyelinating CMT) or in motor/sensory neurons (axonal CMT). More than 120 causative CMT-related genes have been identified so far. Among them, CMT type 2A is the most common axonal form and is linked to mutations in the MFN2 gene encoding Mitofusin-2 (MFN2). MFN2 is an important regulator of mitochondrial fusion. Around a hundred mutations have been described and are distributed throughout all the protein's domains. Consequently, gene therapy stra

Mitochondrial dysfunction has been implicated in psychiatric disorders, yet the specific cellular and molecular mechanisms remain elusive. Previous research has identified a connection between high trait anxiety and low levels of mitofusin 2 (Mfn2), a mitochondrial fusion protein, in the nucleus accumbens (NAc), a brain region crucial for motivation and goal-directed behavior. To assess the implications of Mfn2 in a cell-type specific manner, in this study we selectively manipulated Mfn2 in NAc dopamine receptor 1-expressing medium spiny neurons (D1-MSNs) using a viral vector (AAV1-Dyn-CRE) in