Topic: MFSD2A

Healthy brain activity relies on the presence of key astrocytic proteins: the excitatory amino acid transporters (EAAT1/2), inwardly rectifying K+ channel (Kir4.1), aquaporin-4 (AQP4) among others. In the aging cortex, we report a novel phenotype of individual, sparse, non-reactive astrocytes with unchanged morphology, but greatly reduced levels of EAATs, Kir4.1, AQP4, and other astrocytic proteins, while bordering cells retain robust immunolabeling. Astrocyte tiling remains intact leaving these domains without many essential astrocytic functions. Already documented in a concussive mouse model

The increased accumulation of amyloid b (Ab) in retinal blood vessels in Alzheimer’s disease (AD) patients and AD animal models is in significant correlation with the brain amyloid deposits associated with the cognitive impairment in AD. Ab accumulation in blood vessels can be the result of impaired transcytosis and/or the dysfunctional ocular glymphatic system in AD. The supplementation with high-dose fish oil (FO) have shown significant effects in diminishing AD pathologies but also serving as the blood vessel fortifier. We analyzed the changes in expression of major facilitator superfamily