Topic: mGlu5

The metabotropic glutamate receptor, mGlu5, plays a critical role in the persistency of hippocampal long-term potentiation (LTP), long-term depression (LTD) as well as hippocampus-dependent associative learning and memory (doi: 10.3390/cells11213352). Although well-studied, the majority of investigations as to the role of mGlu5 in these processes in rodents has been done during the light cycle that amounts to the resting phase of rodent species. Sleep-states are regulated by mGlu5 (doi: 10.3390/cells12131761) suggesting that its contribution to hippocampal information processing and storage ma

Some individuals with Alzheimer’s disease (AD) pathology exhibit cognitive resilience, offering promising prospects for identifying new therapeutic targets.Aims: Our hypothesis centers around the contribution of resilience to changes in excitatory synapses at the structural and molecular levels, which may underlie healthy cognitive performance in aged AD animals.Methods: We used Morris Water Maze tests, ELISA, western blots, stereological methods and immunoelectron microscopy.Results: Utilizing the Morris Water Maze test, we selected resilient (asymptomatic) and cognitively impaired aged-Tg257

The glutamatergic receptor mGlu5, being a modulator of neurotransmission in regions such as the cortex and hippocampus, plays a crucial role in learning and memory processing. Numerous studies highlight the alteration, contribution, and potential therapeutic targeting of mGlu5 in Alzheimer disease (AD). AD is the first cause of dementia, resulting in significant cognitive deficits, including memory loss due to the accumulation of Aβ, hyperphosphorylated tau, and neurodegeneration. In patients, brain asymmetric alterations, as Aβdepositions more pronounced in the left side, are reported early i